Genetic testing for channelopathies, more than ten years progress and remaining challenges

Genetic testing for channelopathies, more than ten years progress and remaining challenges

47 J Cardiovasc. Dis. Res. Vol. 1 / No 2 in 1996,[4] the identifi cation of mutations and investigation of genotype-phenotype relationships of channelopathies have become focal points in the fi eld of genetics and cardiology. For Brugada syndrome alone, 7 related genes, and hundreds of associated mutations have been identifi ed.[5,6] SCN5A, encoding the Nav1.5 α-subunit, causes the sodium ion c...

More than ten years of DOTS in Bosnia and Herzegovina.

Directly Observed Therapy Short-course (DOTS) is composed of five distinct elements: political commitment, case detection through quality-assured bacteriology; drug supplies; surveillance and monitoring systems and use of highly efficacious regimens; and direct observation of treatment. DOTS produces cure rates of up to 95 percent even in the poorest countries and prevents the development of Mu...

Genetic Testing for Cardiac Ion Channelopathies

Handedness frequency over more than ten thousand years.

Although there are quite important geographical variations in the frequency of left-handers around the world, nothing is known about its temporal evolution. During the upper Palaeolithic (ca. 35,000-10,000 YBP), humans painted 'negative hands' by blowing pigments with a tube onto one hand applied on the rock in caves in Western Europe, by blowing pigments on their own hand through a tube held i...

HIV/AIDS, more than 25 years later: which challenges remain?

The discovery of HIV in 1983 originated from a collective adventure, which mobilized clinicians, researchers and patients altogether. This collaboration was crucial to rapidly expand the knowledge of the virus and develop the first diagnostic tests and antiretroviral therapy (ART). More than 25 years after the discovery of the etiological agent responsible for AIDS, research priorities still re...